Ciliary motion and control
Cilia are critical for normal physiological function of many systems in our body, such as respiratory, reproductive, digestive, excretory , sensory, neural systems, and development. There are diseases caused by ciliary dysfunction. For examples please see
- Cilia-related diseases
- Ciliary syndromes and treatment
- The cell biological basis of ciliary disease
- Secrets of the Cilia
Our eukaryotic ciliary models used in our research share the well-known ‘9 + 2’ basic structure as human cilia. In addition to an advance in basic science knowledge and in reverse engineering of ciliary design and assembly, knowing how the cilia work and being controlled at the cellular and molecular levels will aid in understanding molecular basis of the ciliary-related diseases.
Mistakes or errors in cellular information processing cause diseases such as cancer, autoimmunity, diabetes ,Alzheimer’s , Parkinson’s. Understanding intracellular signaling, dynamically and quantitatively to establish a theoretical model for prediction of malfunction and how to prevent it will be valuable for understanding the cause, treatment and prevention of the diseases.
Knowing what initially happens at the receptor molecule when its chromophore absorbs light adds a critical information to the visual transduction. Rhodopsin is a prototype of G protein catalyzing receptor family which is the majority of receptors for variety of drugs commonly used. Molecular activation of rhodopsin will form a basis to understand how the ligands (drug molecules) react with the pharmacological receptors.